Lack of association of KIF6 genotype with vascular disease and statin response.
نویسنده
چکیده
1. Hopewell JC, Parish S, Clarke R, Armitage J, Bowman L, Hager J, Lathrop M, Collins R; MRC/BHF Heart Protection Study Collaborative Group. No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the Heart Protection Study. J Am Coll Cardiol. 2011;57:2000–2007. 2. Ridker PM, Macfadyen JG, Glynn RJ, Chasman DI. Kinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention. Circ Cardiovasc Genet. 2011;4:312–317.
منابع مشابه
No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study.
OBJECTIVES The aim of this study was to test the effects of the KIF6 Trp719Arg polymorphism (rs20455) on vascular risk and response to statin therapy in 18,348 participants from the Heart Protection Study. BACKGROUND There have been claims that noncarriers of the KIF6 719Arg variant receive little benefit from statin therapy. Screening for this genetic variant is now being used to influence s...
متن کاملRelationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population
The existence of genetic traits might explain the susceptibility to develop hypercholesterolemia and the inter-individual differences in statin response. This study was performed to evaluate whether individuals' polymorphisms in HMG-CoA and KIF6 genes are independently associated with hypercholesterolemia, other lipid-associated traits, and statin response in unselected individuals enrolled in ...
متن کاملKinesin-like protein 6 (KIF6) polymorphism and the efficacy of rosuvastatin in primary prevention.
BACKGROUND Hypothesis-generating data raise the possibility that carriers of the kinesin-like protein 6 (KIF6) 719 arginine (Arg) allele preferentially benefit from statin therapy, and, on this basis, a commercial assay for KIF6 has been developed. METHODS AND RESULTS In the recently completed JUPITER trial, men and women without prior cardiovascular disease or diabetes who had baseline low-d...
متن کاملKIF6 p.Trp719Arg Testing to Assess Risk of Coronary Artery Disease and/or Statin Response Œ PLOS Currents Evidence on Genomic Tests
Coronary artery disease (CAD) is a leading cause of death worldwide and in the United States it is responsible for more than 500,000 deaths each year. Genome-wide association studies (GWAS) have revealed connections between a number of common single nucleotide polymorphisms (SNPs) and CAD and other cardiovascular diseases. The p.Trp719Arg SNP in the kinesin-like family 6 (KIF6) gene has recentl...
متن کاملKIF6 p.Trp719Arg Testing to Assess Risk of Coronary Artery Disease and/or Statin Response
Coronary artery disease (CAD) is a leading cause of death worldwide and in the United States it is responsible for more than 500,000 deaths each year. Genome-wide association studies (GWAS) have revealed connections between a number of common single nucleotide polymorphisms (SNPs) and CAD and other cardiovascular diseases. The p.Trp719Arg SNP in the kinesin-like family 6 (KIF6) gene has recentl...
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ورودعنوان ژورنال:
- Circulation. Cardiovascular genetics
دوره 4 4 شماره
صفحات -
تاریخ انتشار 2011